The product was purified by flash chromatography (CHC13 - 5% MeOH/CHCl3) as an off white solid. DMSO-d6) 2.65 (6H, s, 2 x - CH3), 3.72 (3H, s. -SO4CH3), 4.51 (3H. An additional pyridine formation starting from azaenyne allenes forms α-5-didehydro-3-picoline diradicals, which can be trapped by 1,4-cyclohexadiene, chloroform, and methanol to produce various pyridines <2004OL2059>. As might be expected, the free energy difference between the two principal conformers was found to be small, increasing with the size of the substituents. These findings reveal that pyridine molecules not only adsorb onto the external surface of sepiolite but are also incorporated in its channels and tunnels with adsorption taking place at corners and/or edges, depending on the position of water molecules. It should be appreciated that references to a compound in this specification, including the claims, are intended to refer, where appropriate, to a corresponding salt of that compound. Epub 2010 Jan 6. then R, is H and R, is Cl CH, or Br CH,. The results indicate that 2-aminopyridine and 2,2'-bipyridyl molecules adsorb onto sepiolite through hydrogen bonding of the amino groups to the water molecules in the octahedral sheet and to the surface hydroxyls (Si-OH) in the tetrahedral sheet. 9 0 obj From: Comprehensive Heterocyclic Chemistry III, 2008, P.A. 0.027mol) was dissolved in methanol (150ml) in a 2-necked round bottom flask and heated to reflux. On cooling, the pH of the solution was adjusted to 10 by addition of sodium hydroxide solution (10M, 100ml). Separation and purification of these compounds was carried out by flash chromatography (CHC1, - 5% CH,OH/CHCl,). CDCI3) 8.50 (2H, s. 2-H, 6-H) and 2.38 (6H, s. 2 x - CH3). Note that thiourea (TU) derivatives can be considered as weak electrophiles due to their H-bonding donor ability.31 Such organic catalytic systems lead to cooperative activation of the monomer and initiator (see Section s, 6-H). Decolorization of vegetable oils: chlorophyll-a adsorption by acid-activated sepiolite. 2-Amino-oxazoline and 2-aminothiazoline (Figure 1) are organocatalysts whose structure exhibits similarities with that of TBD.40 Indeed, both 2-aminothiazoline and 2-amino-oxazolines have a three-centered –N=C–NH– moiety, like TBD. 16. This mixture was then filtered and concentrated to yield a crude brown oil. The insoluble material was then filtered and the solvent removed in vacuo to yield a pale yellow-orange product. According to the process described in EP103553-A, two consecutive reactions are performed on the pyridine nucleus at the 4-position. Η-NMR analysis of this product indicates that the nucleophilic substitution had taken place. 0.027mol) was dissolved in methanol (150ml) in a 2-necked round bottom flask and heated to reflux. According to the present invention there is provided a compound of the formula. In this respect, bifunctional organocatalysts find analogies with multicentered enzymatic catalysis, which allows synergistic interactions with the different reaction partners with high selectivities. The two most abundant products are 182 and 183 (Equation 95) <2002J(P1)542>. Compound IV and VI may be converted to compounds such as 2-chloromethyl-4- hydroxy-3,5-butidine hydrochloride which in turn may be used to prepare omeprazole derivatives in which the 4-pyridine position is substituted by groups such as benzyloxy and aryloxy. 8%), 216 (NT - SO4Me, 14%), 201 (100%). % yield = 76% δH (500MHz, CDCI3) 2.45 (3H, s,-CH,), 2.46 (3H, s, CH3), 4.09 (3H, s, OCH3), 5.10 (2H, s, CH2OH) and 8.35 (1H, s, 6-H). /CropBox [0 0 595 842] Examples of such agents are acrylamide, acrylic esters and chloropropionic acid esters.

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